Resource Library

Data Sheet: GORE Protein Capture Device for Early Clinical Applications, 9.0mL (PROA103)

The 9.0mL Device (PROA103) GORE Protein Capture Device provides performance advantages over traditional agarose resin columns in late stage discovery, pre-clinical and early clinical applications.

Application Note: Sodium Hydroxide (NaOH) Exposure Conditions for Successful Operation of GORE® Protein Capture Devices with Protein A for Drug Discovery Applications

Data shows the 1.0 mL and 3.5 mL GORE® Protein Capture Devices (PROA101, PROA102) withstand up to 50 purification cycles with 0.5 M NaOH. Even after repeated sodium hydroxide exposure, they maintain yield, capacity, and purity—supporting efficient Protein A chromatography.

Application Note: Rapid Cycling using the GORE® Protein Capture Device with Protein A, 58 mL for Clinical Applications

Evaluation of the 58 mL GORE® Protein Capture Device (PROA201) with clarified CHO cell harvest showed higher productivity by increasing non-loading flow rates while maintaining yield, purity, and elution widths—ensuring consistent quality in bioprocessing.

Application Note: Increase Productivity with a Simulated Moving Bed Chromatography Technique

Evaluate the GORE® Protein Capture Device with Protein A combined with a simulated moving bed chromatography technique, CaptureSMB(TM), to increase the productivity of IgG purification. A joint study with Athena Enzyme Systems and Gore & Associates.

Application Note: Extended Cycling Durability, High Productivity Membrane-Based Affinity Purification using GORE® Protein Capture Devices with Protein A

This application note provides data demonstrating high productivity, extended cycling durability performance of membrane-based GORE® Protein Capture Devices with Protein A across two rapid Clean-in-Place methods bracketing caustic contact time and concentration.

Application Note: Evaluation of Dynamic Binding Capacity and Residence Time of Membrane-Based GORE® Protein Capture Device with Protein A

Boehringer-Ingelheim testing showed GORE® Protein Capture Devices with Protein A can cut process time and boost yields in monoclonal antibody purification. Unlike agarose bead columns, Gore’s devices may eliminate extra downstream concentration steps for greater efficiency.

Application Note: Differential Fab Binding to GORE® Protein Capture Devices

A detailed application note demonstrates how GORE® Protein Capture Devices with Protein A show differential Fab fragment binding based on VH3 residue 57 mutations—guiding antibody design for improved capture, yield and purification workflows.

Application Note: Delivering Consistent Protein A Membrane Scalability, GORE® Protein Capture Devices with Protein A

This application note demonstrates the scalability across multiple GORE Protein Capture Device sizes through dynamic binding capacity, CHO cell harvest, and purification experiments as demonstrated with a partially purified monoclonal antibody.