Resource Library

White Paper: Overcoming Barriers to Adopting Membrane Technology, GORE Protein Capture Devices with Protein A

Comparability in both product quality and chromatographic process characteristics between a Protein A affinity capture membrane and a packed-bed resin reference was demonstrated using a set of proposed criteria.

White Paper: Building a Fully Single-Use Process, High Productivity Protein A Membrane Devices that Complement Disposable Upstream Technology

A fully single-use downstream process for mAb harvest at manufacturing scale showed high productivity affinity capture, supporting titers up to 10 g/L at 2000 L. Combined with prior data, results highlight the potential of GORE® Protein Capture Devices for scalable bioprocessing.

Technical Note: Reverse flow cycles at higher flow rates with the GORE® Protein Capture Device with Protein A

This technical note demonstrates that the GORE® Protein Capture Device (GPCD) PROA201 is capable of reverse flow cycles up to 30srt flow rates to facilitate air expulsion without significant impact to column operating pressure, flow characteristics and binding capacity.

Technical Note: Hydrodynamic Shear and Turbulent Flow Considerations for High Productivity Membrane Affinity Chromatography

Therapeutic antibodies face hydrodynamic forces and material interactions during manufacturing that can affect stability and aggregation. As batch sizes scale, fluid flow rates and component design must be carefully managed to maintain protein quality and process reliability.

Technical Note: Carryover Analysis of GORE Protein Capture Devices with Two Monoclonal Antibodies

This technical note provides evidence based through ELISA assays that the GORE® Protein Capture Device did not have carryover after consecutive cycling of two different cell culture harvests when separated by a 15-minute sanitization cycle using 0.1 M NaOH.

Operating Instructions: GORE® Protein Capture Devices for Drug Discovery Applications

General handling, antibody purification protocol, troubleshooting, and ordering information.

Operating Instructions: GORE® Protein Capture Device for 58 mL through 1 L

General handling, antibody purification protocol and troubleshooting guide for 58mL (PROA201), 116 mL (PROA202), 232 mL (PROA203), 250 mL (PROA301), 500 mL (PROA302), and 1L (PROA303).

Operating Instructions: GORE Protein Capture Device for Early Clinical Applications, 9.0mL (PROA103)

General handling, antibody purification protocol and troubleshooting guide for PROA103.

Datasheet: GORE® Protein Capture Device 58 mL through 1 L

GORE Protein Capture Devices with Protein A are intended for the affinity purification of monoclonal antibodies and other proteins containing an Fc region derived from clarified cell culture harvests in process development to initial GMP clinical applications.

Data Sheet: GORE® Protein Capture Devices

GORE Protein Capture Devices use a unique expanded polytetrafluorethylene (ePTFE) membrane composite that provides a binding capacity advantage at high flow rates to improve the speed of purification in drug discovery applications.