Application Note: Sodium Hydroxide (NaOH) Exposure Conditions for Successful Operation of GORE^® Protein Capture Devices with Protein A for Drug Discovery Applications

This application note provides data to support sodium hydroxide (NaOH) exposure limits for the 1.0mL and 3.5mL GORE Protein Capture Devices (PROA101 and PROA102). The cycling protocol utilizing 0.5 molar (M) NaOH supports 50 purification cycles with minimal impact to purification yield, device capacity, or assessed purity.