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DATASHEET:  GORE Protein Capture Device for Early Clinical Applications

The 9.0mL Device (PROA103) GORE Protein Capture Device provides performance advantages over traditional agarose resin columns in late stage discovery, pre-clinical and early clinical applications.

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Image of Data Sheet for GORE® Protein Capture Devices

Chromatography

GORE Protein Capture Devices use a unique expanded polytetrafluorethylene (ePTFE) membrane composite that provides a binding capacity advantage at high flow rates to improve the speed of purification in drug discovery applications.

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Image of Operating Instructions for GORE® Protein Capture Devices

Chromatography

General handling, antibody purification protocol, troubleshooting, and ordering information.

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Document image: GORE Protein Capture Device for Early Clinical Applications, 9.0mL (PROA103) - Operating Instructions

Chromatography

General handling, antibody purification protocol and troubleshooting guide for PROA103.

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Protein Capture Device Protein A reverse flow cycles

Pharmaceutical & Biopharmaceutical

This application note demonstrates the scalability across multiple GORE Protein Capture Device sizes through dynamic binding capacity, CHO cell harvest, and purification experiments as demonstrated with a partially purified monoclonal antibody.

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Protein Capture Device Protein A reverse flow cycles

Pharmaceutical & Biopharmaceutical

This application note demonstrates utilizing a rapid CIP and optimizing the loading and non-loading residence times during cycling to achieve increased productivity on a Gore Protein Capture Device. The method is easily transferred from lab scale to pilot scale sizes as demonstrated using both PROA101 (1mL) and PROA201 (58 mL) Gore Protein Capture Devices.

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Thumbnail image of Technical Note

Pharmaceutical & Biopharmaceutical

This technical note provides evidence based through ELISA assays that the GORE® Protein Capture Device did not have carryover after consecutive cycling of two different cell culture harvests when separated by a 15-minute sanitization cycle using 0.1 M NaOH.

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50-ml Stability container

Single-Use Frozen Storage

Engineered from the same materials of construction as the GORE STA-PURE Flexible Freeze Container, the 50-ml Stability container assembly is designed to support testing during drug substance development.

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Thumbnail image of data sheet document for GORE® STA-PURE® Flexible Freeze Container

Single-Use Frozen Storage

Single-use GORE® STA-PURE® Flexible Freeze Containers are intended for handling, transport and storage of frozen bulk drug substances after freezing at -86°C (-123°F).

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GORE Protein Capture Device for Early Clinical Applications, 9.0mL (PROA103)

This unique membrane Device offered in 9.0 mL has a capacity of ≥ 360 mg when using 1.25 mg/mL human polyclonal hIgG in phosphate-buffered solution at 30 seconds residence time (SRT).  Request the Validation Guide for complete testing details.

This document is available upon request.

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