Resource Library

The 9.0mL Device (PROA103) GORE Protein Capture Device provides performance advantages over traditional agarose resin columns in late stage discovery, pre-clinical and early clinical applications.

GORE Protein Capture Devices use a unique expanded polytetrafluorethylene (ePTFE) membrane composite that provides a binding capacity advantage at high flow rates to improve the speed of purification in drug discovery applications.

General handling, antibody purification protocol, troubleshooting, and ordering information.

General handling, antibody purification protocol and troubleshooting guide for PROA103.

This application note demonstrates the scalability across multiple GORE Protein Capture Device sizes through dynamic binding capacity, CHO cell harvest, and purification experiments as demonstrated with a partially purified monoclonal antibody.

This application note demonstrates utilizing a rapid CIP and optimizing the loading and non-loading residence times during cycling to achieve increased productivity on a Gore Protein Capture Device. The method is easily transferred from lab scale to pilot scale sizes as demonstrated using both PROA101 (1mL) and PROA201 (58 mL) Gore Protein Capture Devices.

This technical note provides evidence based through ELISA assays that the GORE® Protein Capture Device did not have carryover after consecutive cycling of two different cell culture harvests when separated by a 15-minute sanitization cycle using 0.1 M NaOH.

Engineered from the same materials of construction as the GORE STA-PURE Flexible Freeze Container, the 50-ml Stability container assembly is designed to support testing during drug substance development.

Single-use GORE® STA-PURE® Flexible Freeze Containers are intended for handling, transport and storage of frozen bulk drug substances after freezing at -86°C (-123°F).

This unique membrane Device offered in 9.0 mL has a capacity of ≥ 360 mg when using 1.25 mg/mL human polyclonal hIgG in phosphate-buffered solution at 30 seconds residence time (SRT).  Request the Validation Guide for complete testing details.

This document is available upon request.