Categories
Technical Note: Reverse flow cycles at higher flow rates with the GORE® Protein Capture Device with Protein A

Chromatography

This technical note demonstrates that the GORE® Protein Capture Device (GPCD) PROA201 is capable of reverse flow cycles up to 30srt flow rates to facilitate air expulsion without significant impact to column operating pressure, flow characteristics and binding capacity.

English (U.S.)

Data Sheet: GORE<sup>®</sup> IMPROJECT<sup>®</sup> Plungers

Drug Delivery and Packaging

GORE® IMPROJECT® Plungers eliminate the need for silicone as a lubricant in pre-filled syringes. Used with bare-glass (non-siliconized) barrels, these silicone-free plungers provide consistent delivery performance over time, and can protect complex or sensitive biologics from silicone-induced aggregation and particulation.

English (U.S.)

Validation Guide: GORE® IMPROJECT® Plungers

Drug Delivery and Packaging

A comprehensive guide for validating these plungers for use in bare-glass (non-siliconized) pre-filled syringe barrels. GORE® IMPROJECT® plungers can help to protect the stability of complex, silicone-sensitive biologics, while providing consistent drug delivery performance over time. This document is available upon request.

English (U.S.)

Application Note: Sodium Hydroxide (NaOH) Exposure Conditions for Successful Operation of GORE<sup>®</sup> Protein Capture Devices with Protein A for Drug Discovery Applications

Chromatography

This application note provides data to support sodium hydroxide (NaOH) exposure limits for the 1.0mL and 3.5mL GORE Protein Capture Devices (PROA101 and PROA102). The cycling protocol utilizing 0.5 molar (M) NaOH supports 50 purification cycles with minimal impact to purification yield, device capacity, or assessed purity.

English (U.S.)

Protein Capture Device Chromatography productivity calculator

Chromatography

Discover how rapid cycle Protein A membrane chromatography can boost your antibody purification process productivity by trying the new GORE® Productivity Calculator.

A few quick inputs and you will see the difference high flow, high binding membranes can make. Please fill out form below to request the document.

English (U.S.)

Operating Instructions: GORE Protein Capture Device for 58mL, 116 mL, and 232 mL

Chromatography

General handling, antibody purification protocol and troubleshooting guide for 58mL (PROA201), 116 mL (PROA202), and 232 mL (PROA203).

English (U.S.)

GORE Protein Capture Device 58mL

Chromatography

GORE Protein Capture Devices with Protein A are intended for the affinity purification of monoclonal antibodies and other proteins containing an Fc region derived from clarified cell culture harvests in process development to initial GMP clinical applications.

English (U.S.)

Image of app note

Chromatography

This evaluation demonstrates a method to improve productivity by increasing flow rates for the non-loading steps with a representative clarified CHO cell harvest with the 58mL, GORE Protein Capture Device (PROA201) and maintaining critical quality attributes including yield, purity and elution widths.

English (U.S.)

GORE Flexible Freeze Container cold durability

Single-Use Frozen Storage

When comparing containment systems for cold chain use, it is critical to understand all the factors that can affect performance. Although polymer bags are an excellent choice for this application, not all polymer films perform the same way, even if their specifications rate them for use at low temperatures. A full suite of application testing is necessary to determine whether a bag will hold up to all the rigors of handling and shipping at extremely cold temperatures.

English (U.S.)

Validation Guide: GORE Protein Capture Device 58mL, 116 mL, and 232 mL

Chromatography

Designed for the affinity purification of monoclonal antibodies from clarified cell culture harvest (CCH) streams in process development and clinical applications. Request the Validation Guide for complete testing details for the GORE Protein Capture Device 58mL (PROA201), 116 mL (PROA202), and 232 mL (PROA203).

This document is available upon request.

English (U.S.)