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Application Note:  Extending the Lifetime of GORE™ Protein Capture Devices through Alternative Cycling Parameters

Chromatography

This evaluation demonstrates a method to extend the lifetime of a GORE Protein Capture Device from 20 to 50 cycles while maintaining capacity as assessed by Dynamic Binding Capacity (DBC) at 10% breakthrough, yield, and purity.

English (U.S.)

Application Note: Aragen's A Platform to Rapidly Purify and Formulate Immunoglobulins from Mammalian Expression Systems

Chromatography

Recently introduced technologies such as Protein A membrane devices and tangential flow filtration (TFF) systems capable of handling ultrafiltration and diafiltration of samples as low as 5 mL have significantly decreased the turnaround time.

This document is available upon request.

English (U.S.)

mage of Application Note for GORE™ Protein Capture Device Used in Manual LC Methods

Chromatography

The GORE Protein Capture Device with Protein A can be used as demonstrated in three different manual/semi-automated operations to rapidly purify monoclonal antibodies without an LC unit.

English (U.S.)

Image of Application Note for GORE™ Protein Capture Device Cleaning Protocols

Chromatography

Two cleaning protocols outlined in this application note potentially extend the lifetime of a GORE Protein Capture Device in the event that pressure elevates over the expected lifetime of the device.

English (U.S.)

Image of Application Note for GORE™ Protein Capture Device Used in Series

Chromatography

Two 3.5 mL GORE Protein Capture Devices can be connected in series, which doubles the column capacity by providing a 7.0 mL bed volume and allows capture of at least 200 mg of monoclonal antibody within 60 minutes.

English (U.S.)

Thumbnail image of Application Note

Chromatography

Boehringer-Ingelheim evaluated GORE Protein Capture Devices with Protein A vs. a traditional agarose bead column and found that, together with high titers, the GORE column can reduce overall process time and may help increase yields in monoclonal antibody purification by eliminating the need for additional downstream concentration steps.

English (U.S.)

Increasing the Productivity of mAb Purification using the GORE Protein Capture Devices with Protein A

Chromatography

Evaluate the impact of increasing operational flow rate steps (e.g. equilibrations, washes, and clean-in-place (CIP)) on the overall productivity (mg mAb/hour) of GORE Protein Capture Devices (PROA101 & PROA102).

English (U.S.)

Brochure cover shows a lab technician in protective gear operating test machinery.

Pharmaceutical & Biopharmaceutical

Gore’s rigorously compliant, technology-driven products and process components designed for efficiency, reliability and contamination control.

English (U.S.)

Image of Data Sheet for GORE™ Protein Capture Devices

Chromatography

Designed for small-scale affinity purification of monoclonal antibodies, GORE Protein Capture Devices provide high binding capacity at short residence time with the potential for fewer process steps.

English (U.S.)

Image of Operating Instructions for GORE™ Protein Capture Devices

Chromatography

General handling, antibody purification protocol, troubleshooting, and ordering information.

English (U.S.)