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GORE Protein Capture Device for Early Clinical Applications, 9.0mL (PROA103)

This unique membrane Device offered in 9.0 mL has a capacity of ≥ 360 mg when using 1.25 mg/mL human polyclonal hIgG in phosphate-buffered solution at 30 seconds residence time (SRT).  Request the Validation Guide for complete testing details.

This document is available upon request.

English (U.S.)

DATASHEET:  GORE Protein Capture Device for Early Clinical Applications

The 9.0mL Device (PROA103) GORE Protein Capture Device provides performance advantages over traditional agarose resin columns in late stage discovery, pre-clinical and early clinical applications.

English (U.S.)

Image of Data Sheet for GORE® Protein Capture Devices

Chromatography

GORE Protein Capture Devices use a unique expanded polytetrafluorethylene (ePTFE) membrane composite that provides a binding capacity advantage at high flow rates to improve the speed of purification in drug discovery applications.

English (U.S.)

GORE Protein Capture Device 58mL

Chromatography

GORE Protein Capture Devices with Protein A are intended for the affinity purification of monoclonal antibodies and other proteins containing an Fc region derived from clarified cell culture harvests in process development to initial GMP clinical applications.

English (U.S.)

Image of GORE® Protein Capture Devices Validation Guide

Chromatography

Designed for small-scale affinity purification of monoclonal antibodies, GORE Protein Capture Devices provide high binding capacity at short residence time with the potential for fewer process steps.

This document is available upon request.

English (U.S.)

Validation Guide: GORE Protein Capture Device 58mL, 116 mL, and 232 mL

Chromatography

Designed for the affinity purification of monoclonal antibodies from clarified cell culture harvest (CCH) streams in process development and clinical applications. Request the Validation Guide for complete testing details for the GORE Protein Capture Device 58mL (PROA201), 116 mL (PROA202), and 232 mL (PROA203).

This document is available upon request.

English (U.S.)

Application Note: Aragen's A Platform to Rapidly Purify and Formulate Immunoglobulins from Mammalian Expression Systems

Chromatography

Recently introduced technologies such as Protein A membrane devices and tangential flow filtration (TFF) systems capable of handling ultrafiltration and diafiltration of samples as low as 5 mL have significantly decreased the turnaround time.

This document is available upon request.

English (U.S.)

Thumbnail image of Application Note

Chromatography

Boehringer-Ingelheim evaluated GORE Protein Capture Devices with Protein A vs. a traditional agarose bead column and found that, together with high titers, the GORE column can reduce overall process time and may help increase yields in monoclonal antibody purification by eliminating the need for additional downstream concentration steps.

English (U.S.)

Increasing the Productivity of mAb Purification using the GORE Protein Capture Devices with Protein A

Chromatography

Evaluate the impact of increasing operational flow rate steps (e.g. equilibrations, washes, and clean-in-place (CIP)) on the overall productivity (mg mAb/hour) of GORE Protein Capture Devices (PROA101 & PROA102).

English (U.S.)

Application Note:  Extending the Lifetime of GORE® Protein Capture Devices

Chromatography

This evaluation demonstrates a method to extend the lifetime of a GORE Protein Capture Device from 20 to 50 cycles while maintaining capacity as assessed by Dynamic Binding Capacity (DBC) at 10% breakthrough, yield, and purity.

English (U.S.)