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An intensified and fully single use downstream operation was demonstrated to process a monoclonal antibody cell culture harvest at a manufacturing scale.  The results of the study were combined with previously published data to show the potential for high productivity affinity capture sufficient up to 10 g/L titers at the 2000 L scale.

GORE® Microfiltration Media help design engineers and program managers of Original Equipment Manufacturers (OEMs) and Contract Development Manufacturing Organizations (CDMOs) of diagnostics equipment and consumables to develop molecular diagnostic (MDx) panels with consistent and precise fluid movement thus enabling accurate and reliable test results. Unlike other filter or vent options Gore’s vent solutions are engineered to work with aggressive reagents and solvents giving more degrees of freedom in cartridge design enabling the most cost-effective designs.

The 9.0mL Device (PROA103) GORE Protein Capture Device provides performance advantages over traditional agarose resin columns in late stage discovery, pre-clinical and early clinical applications.

General handling, antibody purification protocol and troubleshooting guide for PROA103.

General handling, antibody purification protocol, troubleshooting, and ordering information.

GORE Protein Capture Devices use a unique expanded polytetrafluorethylene (ePTFE) membrane composite that provides a binding capacity advantage at high flow rates to improve the speed of purification in drug discovery applications.

GORE® Microfiltration Media for Negative Wound Pressure Therapy (NPWT) act as a filter which help medical device manufacturers for NPWT to ensure proper functionality and longevity of the NPWT systems. Unlike other barrier materials GORE Microfiltration Media provide exudate containment and aerosol filtration as well as proper functioning of the equipment's control units.

For more than 20 years GORE® Microfiltration Media for Infusion Sets have enabled medical device manufacturers to design IV filters with reliable micro-gas bubble evacuation while containing fluids and maintaining sterility.

Unlike other materials, GORE Microfiltration Media for Infusion Sets consistently deliver high performance without membrane surface modification and enable a stable integration process for high volume production.

For more than 20 years GORE® Microfiltration Media help to protect healthcare workers from exposure during the compounding and administration of hazardous drugs. Unlike other materials, GORE Microfiltration Media are highly inert and engineered to contain aggressive reagents and solvents. Therefore, our PTFE laminate is the first choice when it comes to designing reliable closed system transfer devices (CSTD).

Designed for the affinity purification of monoclonal antibodies from clarified cell culture harvest (CCH) streams in process development and clinical applications. Request the Validation Guide for complete testing details for the GORE Protein Capture Device 58mL (PROA201), 116 mL (PROA202), 232 mL (PROA203), 250 mL (PROA301), 500 mL (PROA302), and 1L (PROA303).

This document is available upon request.