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This document is available upon request. English (U.S.) Chromatography Application Note: Evaluation of Dynamic Binding Capacity and Residence Time of Membrane-Based GORE® Protein Capture Device with Protein A Technical Information, 437.86 KB Boehringer-Ingelheim evaluated GORE Protein Capture Devices with Protein A vs. a traditional agarose bead column and found that, together with high titers, the GORE column can reduce overall process time and may help increase yields in monoclonal antibody purification by eliminating the need for additional downstream concentration steps. English (U.S.) Chromatography Application Note: Increasing the Productivity of mAb Purification using the GORE® Protein Capture Devices with Protein A Technical Information, 329.56 KB Evaluate the impact of increasing operational flow rate steps (e.g. equilibrations, washes, and clean-in-place (CIP)) on the overall productivity (mg mAb/hour) of GORE Protein Capture Devices (PROA101 & PROA102). English (U.S.) Chromatography Application Note: Extending the Lifetime of GORE® Protein Capture Devices through Alternative Cycling Parameters Technical Information, 147.61 KB This evaluation demonstrates a method to extend the lifetime of a GORE Protein Capture Device from 20 to 50 cycles while maintaining capacity as assessed by Dynamic Binding Capacity (DBC) at 10% breakthrough, yield, and purity. English (U.S.) Chromatography Application Note: Cleaning Protocols to Reduce Effects of Pressure Rise Over the Lifetime of a GORE® Protein Capture Devices Technical Information, 471.19 KB Two cleaning protocols outlined in this application note potentially extend the lifetime of a GORE Protein Capture Device in the event that pressure elevates over the expected lifetime of the device. English (U.S.) Application Note: Increase Productivity with a Simulated Moving Bed Chromatography Technique Technical Information, 819.62 KB Evaluate the GORE® Protein Capture Device with Protein A combined with a simulated moving bed chromatography technique, CaptureSMB(TM), to increase the productivity of IgG purification. A joint study with Athena Enzyme Systems and Gore & Associates. English (U.S.) Chromatography Operating Instructions: GORE Protein Capture Device for Early Clinical Applications, 9.0mL (PROA103) Technical Information, 139.71 KB General handling, antibody purification protocol and troubleshooting guide for PROA103. English (U.S.) Chromatography Application Note: Evaluation of 3.5 mL GORE® Protein Capture Devices Used in Series for Monoclonal Antibody Purification Technical Information, 177.2 KB Two 3.5 mL GORE Protein Capture Devices can be connected in series, which doubles the column capacity by providing a 7.0 mL bed volume and allows capture of at least 200 mg of monoclonal antibody within 60 minutes. English (U.S.) Chromatography Application Note: Alternative Method for mAb Purification; Rapid Purification without a Liquid Chromatography Unit using a GORE® Protein Capture Device Technical Information, 338.72 KB The GORE Protein Capture Device with Protein A can be used as demonstrated in three different manual/semi-automated operations to rapidly purify monoclonal antibodies without an LC unit. English (U.S.) Chromatography Operating Instructions: GORE® Protein Capture Devices for Drug Discovery Applications Technical Information, 161.64 KB General handling, antibody purification protocol, troubleshooting, and ordering information. English (U.S.) Load more resources