The growth of non-invasive delivery systems is driving the need for innovative and multi-functional devices and components. These systems can enhance patient compliance and effectively deliver proteins, peptides and biologics. One key challenge is making reliable, sophisticated components that are simple to incorporate into device design and production.
A reliable barrier against contamination
GORE™ Membranes have been used in medical devices for over 25 years. Typical applications include IV vents to remove air from parenteral solutions, hemodialysis transducer protectors, urine bag vents, cell culture flasks and nasal spray pump vents. In each application, GORE™ Membranes for sterile venting enable air permeability or gas exchange while removing airborne pathogens.
Designed for unique delivery needs
Drug formulations depend on the integrity and performance of the packaging components and mechanical systems in order to maintain sterility. GORE™ Membranes block liquids while allowing air to flow through their microporous structures. The incoming air is filtered, which reduces the risk of viral and bacterial contamination. This feature may enable the use of preservative-free drug formulations.
Using Gore membrane technology in a drug delivery device, such as a nasal pump sprayer, produces a highly functional component that equalizes pressure and enables sterile, consistent dosing. GORE™ Membranes for sterile venting allow device engineers to create closed systems by replacing expensive, complex, mechanical solutions that can often stick and leak.
The science behind the solution
GORE™ Membranes combine liquid resistance and airflow through the use of expanded polytetrafluoroethylene (ePTFE). They are hydrophobic, non-particulating, sterilizable and can be engineered with a variety of specific properties. The unique inert, non-reacting, biocompatible properties of ePTFE membranes make them excellent materials for use in pharmaceutical and medical venting applications where sterility is critical.
For example, a 0.2 µ reference pore size GORE™ Membrane removes more than 99.9999% of aerosolized particles, bacteria and GORE™ Membranes for sterile venting breathe viruses. Please see your Gore representative for analytical testing. while repelling liquid, particles and pathogens.
Design Versatility for all venting needs
GORE™ Membranes have been successfully integrated into many configurations, including molded components, cap liners and induction liners. Each form offers its own unique properties to meet the various installation needs of the customer. Known for reliability, innovation and rigorous fitness-for-use testing, Gore develops device and formulation specific solutions.
Integration is simple and straightforward
Incorporating Gore venting technology into a device design is easy. GORE™ Membranes are available in a wide variety of forms that fit nearly any application. Molded components, cap liners and induction liners are most common, but assembled caps and cut parts are also available. Installation may be simply a matter of replacing the current vent or cap.
Design considerations
The following design criteria should be considered prior to specifying GORE™ Membranes. Based on its experience, Gore can provide guidance on factors such as:
- membrane structure
- fluid containment
- fluid surface tension
- airflow rates
- housing materials
- size or real estate
- biological/chemical compatibility
- membrane quality/consistency
- fluid operating pressure
- temperature
- sterilization methods
