Pharmaceutical

Lyophilization in the Pharmaceutical and Biotechnology Industries


GORE™ Lyoguard Lyophilization Products: Improving Lyophilization Operations While Reducing Product Contamination Risk

For more than 50 years, lyophilization — or freeze-drying — has been an effective method used in laboratory and commercial production for stabilizing and preserving valuable, heat-sensitive products. Products commonly preserved by lyophilization include: pharmaceutical and biotechnology drug formulations, nutraceuticals, cosmeceuticals, biomaterials, blood plasma, bacteria and other microorganisms. Lyophilization and freeze-drying are synonymous terms and can be used interchangeably.

The key concept of lyophilization is sublimation – a process where a substance changes from a solid to a vapor without passing through a liquid phase. When comparing freeze-dried products with their liquid counterparts, they have:

  • Longer shelf life
  • Less cumbersome storage, handling and distribution requirements
  • Lower shipping costs because of reduced weight, especially for bulk applications
  • Reduced need for cold storage environments


Stabilize liquid drug formulations and/or parenterals through lyophilization

The process of freeze-drying is used often to stabilize delicate and heat-sensitive materials and compounds such as:

  • proteins
  • peptides
  • biologics
  • vaccines
  • enzymes
  • microorganisms
  • monoclonal antibodies
  • parenterals
  • pharmaceuticals
  • blood fractions
  • oglionucleotides
  • blood plasma
  • diagnostics
  • nutraceuticals
  • cosmeceuticals
  • biomaterials


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GORE™ LYOGUARD FAQ

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Products for the next generation of lyophilization

GORE™ LYOGUARD® Freeze-Drying Products have modernized the way in which the pharmaceutical and biotechnology industries process drugs providing unique solutions to the sterility and processing challenges of lyophilization.